PROGRAM
|
|
|
|
Glycosaminoglycan (GAG) biology: newest advances in basic research, technological developments
and clinical applications
|
|
June 19-21, 2019 - Bordeaux, France
|
|
Wednesday June, 19th 2019
|
|
14:30 - 15:00
|
Reception of participants
|
| |
|
|
15:00 - 15:10
|
Welcome and presentation by the organizers
|
| |
|
|
15:10 - 15:50
|
General introduction : Speaker to be confirmed
|
| |
|
|
SESSION I
|
On the roots of GAG Biosynthesis and Metabolism |
| |
|
|
15:50 - 16:30
|
Effect of biosynthesis enzyme interactions on heparan sulfate structure
Léna Kjellen (Uppsala University, Sweden)
|
| |
|
| 16:30 - 17:00 |
Coffee Break and Poster Session |
| |
|
|
17:00 - 17:40
|
Heparan Sulfate Sulfotransferases: Structural Insight into Substrate Specificity
Lars Pedersen (NIEHS/NIH, Chapel Hill, USA)
|
| |
|
|
17:40 - 18:20
|
Exploration of cell surface and extracellular chondroitin/dermatan sulfate function and its possible use in therapy
Anders Malmström (Lund University, Sweden)
|
| |
|
|
18:20 - 19:00
|
Sub-domain organization of SULF extracellular sulfatases : structural and functional consequences
Romain Vivès (Institut de Biologie Structurale, Grenoble, France)
|
| |
|
|
19:00 - 19:40
|
Inborn errors of GAG metabolism
Sylvie Fournel Gigleux (Nancy University, France)
|
| |
|
19:40
|
Dinner |
| |
| |
|
Thursday June, 20th 2019
|
| |
| 06:30 - 08:50 |
Breakfast
|
|
SESSION II
|
GAG-protein interactions: structure/function relationships and physiopathology
|
| |
|
|
08:50 - 09:30
|
Characterization of Heparan Sulfate and Receptor binding sites on chemokines to understand how GAG
regulate chemokine mediated cell migration
Hugues Lortat-Jacob (Institut de Biologie Structurale, Grenoble, France)
|
| |
|
|
09:30 - 10:10
|
Heparan sulfate as a regulator of chondrocyte differentiation
Andrea Vortkamp (Essen University, Allemagne)
|
| |
|
|
10:10 - 10:40
|
Coffee Break and Poster Session
|
| |
|
|
10:40 - 11:20
|
Role of GAGs in tumor cell internalization of lipoproteins and exosomes
Mattias Belting (Lund University, Lund, Sweden)
|
| |
|
|
11:20 - 12:00
|
Heparan Sulfates altered cellular location: consequences in neurodegeneration
Dulce Papy-Garcia (Université Paris Est, Créteil, France)
|
| |
|
|
12:00 - 12:40
|
Renal glycosaminoglycans as docking platforms for complement factors
Jacob van den Born (Groningen University, Pays-Bas)
|
| |
|
|
12:40 - 14:30
|
Lunch
|
|
SESSION III
|
Technological and methodological approaches for GAG analysis
|
| |
|
|
14:30 - 15:10
|
Analysis of GAG/protein interactions by NMR and Modelling
Pedro M. Nieto (Spanish National Research Council, Sevilla, Spain)
|
| |
|
|
15:10 - 15:50
|
Sequencing of glycosaminoglycans with potential to interrogate sequence-specific interactions
Toin van Kuppevelt (Radboud University, Nijmegen, Pays-bas)
|
| |
|
| 15:50 - 16:30 |
Building and analysis of glycosaminoglycan and proteoglycan interactomes
Sylvie Ricard-Blum (Université de Lyon I, France)
|
| |
|
|
16:30 - 17:00
|
Coffee Break and Poster Session
|
| |
|
|
17:00 - 17:40
|
Chemical GAGobiology: chemistry for tailored probes
David Bonnaffé (Institut de Chimie Moléculaire et des Matériaux d'Orsay, France)
|
| |
|
|
17:40 - 18:20
|
Expanding the chondroitin- and heparan sulfate glycoproteome by LC - MS/MS
Fredrik Noborn (University of Gothenburg, Sweden)
|
| |
|
|
19:30 - 20:15
|
Cocktail
|
|
20:15
|
Dinner
|
| |
|
|
|
Friday June, 21st 2019
|
| 06:30 - 08:50 |
Breakfast
|
|
SESSION IV
|
GAGs : from bench to bedside
|
| |
|
|
08:50 - 09:30
|
Speaker to be confirmed
|
| |
|
|
09:30 - 10:10
|
How the Regenerating Agents (RGTA®), mimetics of heparan sulfates, open a new branch in
regenerative medicine: a translational medicine saga from bench to patient
Franck Chiappini (OTR3, Paris, France)
|
| |
|
| 10:10 - 10:40 |
Coffee Break and Poster Session |
| |
|
|
10:40 - 11:20
|
GAG-based strategies for treating cartilage disease
Patricia Albanese (Université Paris Est, Créteil, France)
|
| |
|
|
11:20 - 12:00
|
Chemoenzymatic synthesis of heparin and drug discovery
Yongmei Xu (South Carolina University, Chapel Hill, USA)
|
| |
|
|
12:00 - 12:15
|
Conclusion
|
| |
|
| 12:15 - 14:00 |
Lunch |
| 14:00 |
Departure
|
|
|---|
|
|