PROGRAM
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Glycosaminoglycan (GAG) biology: newest advances in basic research, technological developments
and clinical applications
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June 19-21, 2019 - Bordeaux, France
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Wednesday June, 19th 2019
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14:30 - 15:00
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Reception of participants
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15:00 - 15:10
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Welcome and presentation by the organizers
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15:10 - 15:50
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General introduction : Speaker to be confirmed
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SESSION I
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On the roots of GAG Biosynthesis and Metabolism |
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15:50 - 16:30
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Effect of biosynthesis enzyme interactions on heparan sulfate structure
Léna Kjellen (Uppsala University, Sweden)
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16:30 - 17:00 |
Coffee Break and Poster Session |
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17:00 - 17:40
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Heparan Sulfate Sulfotransferases: Structural Insight into Substrate Specificity
Lars Pedersen (NIEHS/NIH, Chapel Hill, USA)
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17:40 - 18:20
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Exploration of cell surface and extracellular chondroitin/dermatan sulfate function and its possible use in therapy
Anders Malmström (Lund University, Sweden)
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18:20 - 19:00
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Sub-domain organization of SULF extracellular sulfatases : structural and functional consequences
Romain Vivès (Institut de Biologie Structurale, Grenoble, France)
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19:00 - 19:40
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Inborn errors of GAG metabolism
Sylvie Fournel Gigleux (Nancy University, France)
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19:40
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Dinner |
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Thursday June, 20th 2019
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06:30 - 08:50 |
Breakfast
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SESSION II
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GAG-protein interactions: structure/function relationships and physiopathology
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08:50 - 09:30
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Characterization of Heparan Sulfate and Receptor binding sites on chemokines to understand how GAG
regulate chemokine mediated cell migration
Hugues Lortat-Jacob (Institut de Biologie Structurale, Grenoble, France)
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09:30 - 10:10
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Heparan sulfate as a regulator of chondrocyte differentiation
Andrea Vortkamp (Essen University, Allemagne)
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10:10 - 10:40
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Coffee Break and Poster Session
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10:40 - 11:20
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Role of GAGs in tumor cell internalization of lipoproteins and exosomes
Mattias Belting (Lund University, Lund, Sweden)
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11:20 - 12:00
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Heparan Sulfates altered cellular location: consequences in neurodegeneration
Dulce Papy-Garcia (Université Paris Est, Créteil, France)
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12:00 - 12:40
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Renal glycosaminoglycans as docking platforms for complement factors
Jacob van den Born (Groningen University, Pays-Bas)
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12:40 - 14:30
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Lunch
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SESSION III
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Technological and methodological approaches for GAG analysis
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14:30 - 15:10
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Analysis of GAG/protein interactions by NMR and Modelling
Pedro M. Nieto (Spanish National Research Council, Sevilla, Spain)
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15:10 - 15:50
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Sequencing of glycosaminoglycans with potential to interrogate sequence-specific interactions
Toin van Kuppevelt (Radboud University, Nijmegen, Pays-bas)
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15:50 - 16:30 |
Building and analysis of glycosaminoglycan and proteoglycan interactomes
Sylvie Ricard-Blum (Université de Lyon I, France)
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16:30 - 17:00
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Coffee Break and Poster Session
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17:00 - 17:40
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Chemical GAGobiology: chemistry for tailored probes
David Bonnaffé (Institut de Chimie Moléculaire et des Matériaux d'Orsay, France)
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17:40 - 18:20
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Expanding the chondroitin- and heparan sulfate glycoproteome by LC - MS/MS
Fredrik Noborn (University of Gothenburg, Sweden)
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19:30 - 20:15
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Cocktail
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20:15
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Dinner
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Friday June, 21st 2019
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06:30 - 08:50 |
Breakfast
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SESSION IV
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GAGs : from bench to bedside
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08:50 - 09:30
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Speaker to be confirmed
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09:30 - 10:10
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How the Regenerating Agents (RGTA®), mimetics of heparan sulfates, open a new branch in
regenerative medicine: a translational medicine saga from bench to patient
Franck Chiappini (OTR3, Paris, France)
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10:10 - 10:40 |
Coffee Break and Poster Session |
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10:40 - 11:20
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GAG-based strategies for treating cartilage disease
Patricia Albanese (Université Paris Est, Créteil, France)
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11:20 - 12:00
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Chemoenzymatic synthesis of heparin and drug discovery
Yongmei Xu (South Carolina University, Chapel Hill, USA)
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12:00 - 12:15
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Conclusion
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12:15 - 14:00 |
Lunch |
14:00 |
Departure
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